TRP canonical 4 and/or 5 channel inhibition reduces aversion‐ and increases reward‐responding in chronically stressed mice


Journal article


Giulia Poggi, Deniz Queisser, Alena Senn, H. Sigrist, D. Kúkeľová, L. Madur, Nagiua Cuomo-Haymour, Mélisse Robert, Sophie Schmid, Adrián Portalés, S. Simard, Naguib Mechawar, B. Hengerer, Stefan Just, Christopher R. Pryce
British Journal of Pharmacology, 2025

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APA   Click to copy
Poggi, G., Queisser, D., Senn, A., Sigrist, H., Kúkeľová, D., Madur, L., … Pryce, C. R. (2025). TRP canonical 4 and/or 5 channel inhibition reduces aversion‐ and increases reward‐responding in chronically stressed mice. British Journal of Pharmacology.


Chicago/Turabian   Click to copy
Poggi, Giulia, Deniz Queisser, Alena Senn, H. Sigrist, D. Kúkeľová, L. Madur, Nagiua Cuomo-Haymour, et al. “TRP Canonical 4 and/or 5 Channel Inhibition Reduces Aversion‐ and Increases Reward‐Responding in Chronically Stressed Mice.” British Journal of Pharmacology (2025).


MLA   Click to copy
Poggi, Giulia, et al. “TRP Canonical 4 and/or 5 Channel Inhibition Reduces Aversion‐ and Increases Reward‐Responding in Chronically Stressed Mice.” British Journal of Pharmacology, 2025.


BibTeX   Click to copy

@article{giulia2025a,
  title = {TRP canonical 4 and/or 5 channel inhibition reduces aversion‐ and increases reward‐responding in chronically stressed mice},
  year = {2025},
  journal = {British Journal of Pharmacology},
  author = {Poggi, Giulia and Queisser, Deniz and Senn, Alena and Sigrist, H. and Kúkeľová, D. and Madur, L. and Cuomo-Haymour, Nagiua and Robert, Mélisse and Schmid, Sophie and Portalés, Adrián and Simard, S. and Mechawar, Naguib and Hengerer, B. and Just, Stefan and Pryce, Christopher R.}
}

Abstract

Pharmacological inhibition of TRPC4 and/or TRPC5 channels reduces Pavlovian aversion memory in stressed mice and reduces amygdala reactivity to aversion in humans with depression. The aims of this mouse study were to improve understanding of these anxiolytic processes, determine whether there are corrective effects on reward processes, and provide further translational evidence for TRPC4/C5 channel brain and neuron distribution.